Design, Synthesis, and Conformational Analysis of Proposed β-Turn Mimics from Isoxazoline-Cyclopentane Aminols.

@article{Memeo2015DesignSA,
  title={Design, Synthesis, and Conformational Analysis of Proposed β-Turn Mimics from Isoxazoline-Cyclopentane Aminols.},
  author={Misal Giuseppe Memeo and Mariella Mella and Valentina Montagna and Paolo Quadrelli},
  journal={Chemistry},
  year={2015},
  volume={21 46},
  pages={16374-8}
}
Constrained aminols from oxazanorbornene derivatives have the geometrical features to be used as β-turn inducers. Four different stereoisomers were prepared and spectroscopically characterized (MD calculations, NMR-titration and VT-NMR experiments). Temperature coefficients in DMSO are indicative for the existence of an intramolecular hydrogen bond… CONTINUE READING