Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).

@article{Lv2016DesignSA,
  title={Design, Synthesis, and Biological Evaluation of Potential Prodrugs Related to the Experimental Anticancer Agent Indotecan (LMP400).},
  author={Peng-Cheng Lv and M. S. Elsayed and K. Agama and C. Marchand and Y. Pommier and M. Cushman},
  journal={Journal of medicinal chemistry},
  year={2016},
  volume={59 10},
  pages={
          4890-9
        }
}
Indenoisoquinoline topoisomerase I (Top1) inhibitors are a novel class of anticancer agents with two compounds in clinical trials. Recent metabolism studies of indotecan (LMP400) led to the discovery of the biologically active 2-hydroxylated analogue and 3-hydroxylated metabolite, thus providing strategically placed functional groups for the preparation of a variety of potential ester prodrugs of these two compounds. The current study details the design and synthesis of two series of… Expand
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