Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors.

@article{Mangiatordi2018DesignSA,
  title={Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors.},
  author={Giuseppe Mangiatordi and Tatiana Guzzo and Eugenio Claudio Rossano and Daniela Trisciuzzi and Domenico Alberga and Giovanni Francesco Fasciglione and Massimiliano Coletta and Alessandra Topai and Orazio Nicolotti},
  journal={ChemMedChem},
  year={2018},
  volume={13 13},
  pages={
          1343-1352
        }
}
Targeting matrix metalloproteinases (MMPs) is a pursued strategy for treating several pathological conditions, such as multiple sclerosis and cancer. Herein, a series of novel tetrahydro-β-carboline derivatives with outstanding inhibitory activity toward MMPs are present. In particular, compounds 9 f, 9 g, 9 h and 9 i show sub-nanomolar IC50 values… CONTINUE READING