Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids.

@article{Han2018DesignSA,
  title={Design, Synthesis, and Antitobacco Mosaic Virus Activity of Water-Soluble Chiral Quaternary Ammonium Salts of Phenanthroindolizidines Alkaloids.},
  author={Guifang Han and Linwei Chen and Qiang Wang and Meng Wu and Yuxiu Liu and Qingmin Wang},
  journal={Journal of agricultural and food chemistry},
  year={2018},
  volume={66 4},
  pages={
          780-788
        }
}
To study the influence of the substituent at the N-10 position on antiviral activity, the chiral quaternary ammonium salt derivatives of R- and S-tylophorine were designed, synthesized, and evaluated for antiviral activity against tobacco mosaic virus (TMV). The bioassay results indicated that most of the designed structural analogues showed good in vivo anti-TMV activity, among which propargyl quaternary ammonium salt compound S-7b showed the best anti-TMV activities (80.5%, 77.6%, 76.6%, 82.1… 
Novel chalcone derivatives containing a 1,2,4-triazine moiety: design, synthesis, antibacterial and antiviral activities.
A series of novel chalcone derivatives containing the 1,2,4-triazine moiety were synthesized and their structures were confirmed by 1H NMR, 13C NMR and elemental analyses. Antiviral bioassays
Two Novel Quassinoid Glycosides with Antiviral Activity from the Samara of Ailanthus altissima
TLDR
Two novel quassinoid glycosides are isolated, named chuglycosides J and K, together with fourteen known lignans from the samara of A. altissima for their anti-tobacco mosaic virus activity and inhibitory effects against the virus multiplication.
Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids
TLDR
In this review, natural PIA and PQA analogues obtained in the last two decades with their herbal origins, key spectroscopic characteristics for structural identification, biological activity with possible SARs and application prospects were systematically summarized.
The potential impacts of tylophora alkaloids and their derivatives in modulating inflammation, viral infections, and cancer.
TLDR
The dynamic mechanism of action of immune modulation in cancer and the immunological aspects of the orally active antitumor agents tylophora alkaloids and their analogues are highlighted and suggested that future cancer treatments will rely on the development of combining tumor-targeted agents and biologic immunotherapies.
Recent Research Progress: Discovery of Anti-Plant Virus Agents Based on Natural Scaffold
Plant virus diseases, also known as “plant cancers”, cause serious harm to the agriculture of the world and huge economic losses every year. Antiviral agents are one of the most effective ways to
Synthesis, antiviral and antibacterial activities and action mechanism of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety
A series of penta-1,4-dien-3-one oxime ether derivatives containing a quinoxaline moiety were synthesized, and their bioactivities and action mechanism were evaluated.
Acceptorless dehydrogenative amination of alkenes for the synthesis of N-heterocycles
Catalytic amination of alkenes is one of the most attractive reactions for the construction of complex heterocycles with nitrogen centers. Herein, we present that synergistic photoredox and
An Efficient Synthesis of Phenanthroindolizidine Core via Hetero Diels-Alder Reaction of In Situ Generated α-Allenylchalcogenoketenes With Cyclic Imines
Synthesis of phenanthroindolizidine core was efficiently achieved through a pathway involving hetero Diels-Alder reaction of α-allenylchalcogenoketenes, generated in situ by thermal [3,3] sigmatropic
Synthesis of Quaternary Carbon-Centered Benzoindolizidinones via Novel Photoredox-Catalyzed Alkene Aminoarylation: Facile Access to Tylophorine and Analogues
Photoredox-catalyzed aminoarylation and thioamination of unactivated alkenes have been developed, providing novel synthetic routes to access synthetically challenging quaternary carbon-centered ben...
...
...