Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative

@article{Bastos2018DesignSE,
  title={Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-N-Acylhydrazone Derivative},
  author={Isadora T. S. Bastos and P. S. M. Pinheiro and F. Costa and M. Rocha and C. M. Sant’Anna and D. Braz and Everton T Souza and M. Martins and E. Barreiro and F. Ferreira and R. Barroso and C. A. M. Fraga},
  journal={Pharmaceuticals},
  year={2018},
  volume={11}
}
Pulmonary arterial hypertension (PAH) is a chronic cardiovascular disease that displays inflammatory components, which contributes to the difficulty of adequate treatment with the available therapeutic arsenal. In this context, the N-acylhydrazone derivative LASSBio-1359 was previously described as a multitarget drug candidate able to revert the events associated with the progression of PAH in animal models. However, in spite of having a dual profile as PDE4 inhibitor and adenosine A2A receptor… Expand
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