Design, Development and Evaluation of rK28-Based Point-of-Care Tests for Improving Rapid Diagnosis of Visceral Leishmaniasis

@inproceedings{Pattabhi2010DesignDA,
  title={Design, Development and Evaluation of rK28-Based Point-of-Care Tests for Improving Rapid Diagnosis of Visceral Leishmaniasis},
  author={Sowmya Pattabhi and Jacqueline Whittle and Raodoh Mohamath and Sayda El-Safi and Garner G. Moulton and Jeffrey A. Guderian and Danny V Colombara and Asem O. Abdoon and Maowia Mohamed Mukhtar and Dinesh Mondal and Javan Esfandiari and Shailendra Kumar and Peter Chun and Steven G Reed and Ajay Bhatia},
  booktitle={PLoS neglected tropical diseases},
  year={2010}
}
BACKGROUND Visceral leishmaniasis (VL) is diagnosed by microscopic confirmation of the parasite in bone marrow, spleen or lymph node aspirates. These procedures are unsuitable for rapid diagnosis of VL in field settings. The development of rK39-based rapid diagnostic tests (RDT) revolutionized diagnosis of VL by offering high sensitivity and specificity in detecting disease in the Indian subcontinent; however, these tests have been less reliable in the African subcontinent (sensitivity range of… CONTINUE READING

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