Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis.

@article{Niederkorn2006DesiccatingSI,
  title={Desiccating stress induces T cell-mediated Sj{\"o}gren's Syndrome-like lacrimal keratoconjunctivitis.},
  author={Jerry Y. Niederkorn and Michael Ethan Stern and Stephen Carl Pflugfelder and Cintia S de Paiva and Rosa Mar{\'i}a Corrales and Jianping Gao and Karyn F. Siemasko},
  journal={Journal of immunology},
  year={2006},
  volume={176 7},
  pages={3950-7}
}
Chronic dry eye syndrome affects over 10 million people in the United States; it is associated with inflammation of the lacrimal gland (LG) and in some cases involves T cell infiltration of the conjunctiva. We demonstrate that environmental desiccating stress (DS) elicits T cell-mediated inflammation of the cornea, conjunctiva, and LG, but not other organs in mice. The lacrimal keratoconjunctivitis (LKC) was mediated by CD4(+) T cells, which, when adoptively transferred to T cell-deficient nude… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 126 extracted citations

Dry eye syndrome: developments and lifitegrast in perspective

Clinical ophthalmology • 2018
View 4 Excerpts
Highly Influenced

Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.

Journal of immunology • 2009
View 3 Excerpts
Highly Influenced

Characterization of effector T cells in dry eye disease.

Investigative ophthalmology & visual science • 2009
View 10 Excerpts
Highly Influenced

Comparison of 0.1%, 0.18%, and 0.3% Hyaluronic Acid Eye Drops in the Treatment of Experimental Dry Eye

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics • 2018

Similar Papers

Loading similar papers…