Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis.

  title={Desiccating stress induces T cell-mediated Sj{\"o}gren's Syndrome-like lacrimal keratoconjunctivitis.},
  author={Jerry Y. Niederkorn and Michael Ethan Stern and Stephen Carl Pflugfelder and Cintia S de Paiva and Rosa Mar{\'i}a Corrales and Jianping Gao and Karyn F. Siemasko},
  journal={Journal of immunology},
  volume={176 7},
Chronic dry eye syndrome affects over 10 million people in the United States; it is associated with inflammation of the lacrimal gland (LG) and in some cases involves T cell infiltration of the conjunctiva. We demonstrate that environmental desiccating stress (DS) elicits T cell-mediated inflammation of the cornea, conjunctiva, and LG, but not other organs in mice. The lacrimal keratoconjunctivitis (LKC) was mediated by CD4(+) T cells, which, when adoptively transferred to T cell-deficient nude… CONTINUE READING


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