Desflurane improves the recovery of the evoked postsynaptic population spike from CA1 pyramidal cells after hypoxia in rat hippocampal slices.

@article{Dimaculangan2006DesfluraneIT,
  title={Desflurane improves the recovery of the evoked postsynaptic population spike from CA1 pyramidal cells after hypoxia in rat hippocampal slices.},
  author={Dwight Dimaculangan and Audr{\'e}e A. Bendo and Rebecca J. A. Sims and James Edward Cottrell and Ira S. Kass},
  journal={Journal of neurosurgical anesthesiology},
  year={2006},
  volume={18 1},
  pages={
          78-82
        }
}
Desflurane is a volatile anesthetic that allows rapid induction and emergence, reduces cerebral metabolism, and enhances tissue perfusion. We studied the effect of treatment with 4%, 6%, and 12% desflurane on hypoxic neuronal damage by comparing the size of the postsynaptic evoked population spike recorded from the cornu ammonis 1 (CA1) pyramidal cell layer of rat hippocampal slices before and 2 hours after a hypoxic insult. When the tissue was treated with 6% desflurane before, during, and… CONTINUE READING
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