Desferrioxamine-mediated inhibition of heme and hemoglobin synthesis in murine erythroleukemia cells: expression of globin genes and commitment to erythroid differentiation.

@article{Gambari1983DesferrioxaminemediatedIO,
  title={Desferrioxamine-mediated inhibition of heme and hemoglobin synthesis in murine erythroleukemia cells: expression of globin genes and commitment to erythroid differentiation.},
  author={Roberto Gambari},
  journal={Cell biology international reports},
  year={1983},
  volume={7 10},
  pages={785-95}
}
The iron-chelator desferrioxamine inhibits heme accumulation and globin synthesis in induced murine erythroleukemia cells, suggesting that iron metabolism can modulate globin gene expression. However we found experimental conditions (12.5 micrograms/ml desferrioxamine) which do not suppress hexamethylenebisacetamide-mediated induction of globin synthesis, commitment of the cells to erythroid differentiation and competence for transcription of beta major globin genes, but prevent heme synthesis… CONTINUE READING
1 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…