Desferrioxamine inhibits induced erythroid differentiation of human leukemic K-562 cells.

@article{Gambari1983DesferrioxamineII,
  title={Desferrioxamine inhibits induced erythroid differentiation of human leukemic K-562 cells.},
  author={Roberto Gambari and Giuseppe Raschell{\'a} and Marco Tripodi and Maria Giulia Farace and Antonio Fantoni},
  journal={Cell differentiation},
  year={1983},
  volume={12 5},
  pages={249-55}
}
The iron chelator desferrioxamine reversibly inhibits heme accumulation and globin synthesis in human leukemic K-562 cells induced to express erythroid genes by butyric acid. These results suggest that iron metabolism can modulate globin gene expression. In addition we describe experimental conditions (6.25 micrograms/ml desferrioxamine) which do not suppress transcription of globin genes and translation of globin mRNA but prevent heme synthesis. Therefore expression of globin genes in butyric… CONTINUE READING

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