Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1.

@article{Balanos2002DesferrioxamineEP,
  title={Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1.},
  author={George Balanos and Keith L. Dorrington and Peter A. Robbins},
  journal={Journal of applied physiology},
  year={2002},
  volume={92 6},
  pages={
          2501-7
        }
}
Hypoxia-inducible factor (HIF)-1 is stabilized by hypoxia and iron chelation. We hypothesized that HIF-1 might be involved in pulmonary vascular regulation and that infusion of desferrioxamine over 8 h would consequently mimic hypoxia and elevate pulmonary vascular resistance. In study A, we characterized the pulmonary vascular response to 4 h of isocapnic hypoxia; in study B, we measured the pulmonary vascular response to 8 h of desferrioxamine infusion. For study A, 11 volunteers undertook… CONTINUE READING

Citations

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