Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-β/Smad p53 Pathway in Rat Model

@inproceedings{Alshabanah2012DesferrioxamineAD,
  title={Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-β/Smad p53 Pathway in Rat Model},
  author={O A Al-shabanah and Abdulaziz Mohammed Aleisa and Mohamed Mahmoud Hafez and Salim Salih Al-Rejaie and Abdulaziz Abdulrhman Al-Yahya and Saleh Abdulrahman Bakheet and Mohamed M. Al-Harbi and Mohamed Mohamed Sayed-Ahmed},
  booktitle={Oxidative medicine and cellular longevity},
  year={2012}
}
Interaction of doxorubicin DOX with iron and the consequent generation of reactive oxygen species (ROS) is a major player in DOX-induced cardiomyopathy. Accordingly, this study has been initiated to investigate the preventive effect of the iron chelator, desferrioxamine (DFX), against DOX-induced acute cardiotoxicity in rats. Male Wistar albino rats were divided into four groups and were injected intraperitoneally (I.P.) with normal saline, a single dose of DOX (15 mg/kg), a single dose of DFX… CONTINUE READING
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dative stress and myocardial gene alterations associated with doxorubicin - induced cardiotoxicity in rats persist for 2 months after treatment cessation

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