Desensitization to nitroglycerin in vascular smooth muscle from rat and human.

@article{Waldman1986DesensitizationTN,
  title={Desensitization to nitroglycerin in vascular smooth muscle from rat and human.},
  author={Scott A. Waldman and Robert M. Rapoport and Robert Ginsburg and Ferid Murad},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 20},
  pages={3525-31}
}
Guanylate cyclase in high speed supernatant fractions obtained from rat thoracic aorta or human coronary arteries pretreated with nitroglycerin exhibited a marked desensitization to activation by nitroglycerin, nitroprusside, and nitric oxide. However, activation of soluble guanylate cyclase by arachidonic acid was unaffected by pretreatment of vessels with nitroglycerin. Furthermore, activation of soluble guanylate cyclase by protoporphyrin IX was increased 4-fold when vessels were pretreated… CONTINUE READING

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