Desensitization to Allopurinol in Localized and Systemic Hypersensitivity Reactions

  title={Desensitization to Allopurinol in Localized and Systemic Hypersensitivity Reactions},
  • Segorbe-Luís
  • Published 2013
Allopurinol (4-hidroxipirazolol piramidine) is the first line therapy employed to treat hyperuricemia. It is an inhibitor of the enzymexanthine oxidase which is responsible for the successive oxidation of hypoxanthine andxanthine, resulting in the production of uric acid [1]. In addition to blocking uric acid production it may also inhibit purine synthesis [2]. Although it is a well-tolerated drug, there are descriptions of HSreactions to treatment with variable degree of incidence and severity… CONTINUE READING
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1 Excerpt

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