Desensitization of the muscarinic acetylcholine receptor of atrium in bullfrogs.

@article{Tokimasa1981DesensitizationOT,
  title={Desensitization of the muscarinic acetylcholine receptor of atrium in bullfrogs.},
  author={Takayuki Tokimasa and Hiroshi Hasuo and Kyozo Koketsu},
  journal={The Japanese journal of physiology},
  year={1981},
  volume={31 1},
  pages={83-97}
}
The membrane of bullfrog atrial muscle is hyperpolarized by an increase of K+ conductance in carbachol-containing Ringer solution. The present experiment demonstrated that both the membrane hyperpolarization and K+ conductance increase showed a decay during prolonged application of carbachol, suggesting desensitization of the muscarinic receptor. Such a decay of the membrane conductance increase was also observed when the membrane potential was clamped at the level of the K+ equilibrium… CONTINUE READING

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