Desensitization of the human vasoactive intestinal peptide receptor (hVIP2/PACAP R): evidence for agonist-induced receptor phosphorylation and internalization.

@article{McDonald1998DesensitizationOT,
  title={Desensitization of the human vasoactive intestinal peptide receptor (hVIP2/PACAP R): evidence for agonist-induced receptor phosphorylation and internalization.},
  author={Terence P. McDonald and Diane M Dinnis and Christine F. Morrison and Anthony J. Harmar},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={865},
  pages={64-72}
}
To investigate the role of phosphorylation and internalization in the desensitization of the hVIP2/PACAP receptor, we expressed a C-terminal epitope-tagged (hemagglutinin; YPYDVPDYASL) receptor in COS7 and HEK293 cell lines. Radiolabeling experiments demonstrated that exposure to agonist induced receptor phosphorylation significantly above basal levels. This receptor phosphorylation was greater than that induced by receptor-independent activation of PKA with forskolin and that induced by co… CONTINUE READING

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