Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors.

@article{Le2001DesensitizationOC,
  title={Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors.},
  author={Yingying Le and Michele A. Wetzel and Weizai Shen and Wanghua Gong and Thomas J Rogers and Earl E. Henderson and Ji ming Wang},
  journal={Clinical immunology},
  year={2001},
  volume={99 3},
  pages={365-72}
}
Chemokine receptors are subjected to heterologous desensitization by activation of formyl peptide receptors. We investigated the cross-talk between formyl peptide receptors and the chemokine receptor CCR5 in human monocyte-differentiated immature dendritic cells (iDC). Monocytes cultured with GM-CSF and IL-4 for 4 days exhibit markers characteristic of iDC and maintain the expression of both formyl peptide receptors FPR and FPRL1, as well as CCR5. Pretreatment of iDC with W peptide (WKYMVm), a… CONTINUE READING

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