Desensitization of canonical transient receptor potential channel 5 by protein kinase C.

@article{Zhu2005DesensitizationOC,
  title={Desensitization of canonical transient receptor potential channel 5 by protein kinase C.},
  author={Mei Hong Zhu and MeeRee Chae and Hyun Jin Kim and Young Mee Lee and Min Ji Kim and Nan Ge Jin and Dong Ki Yang and Insuk So and Ki Young Kim},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={289 3},
  pages={
          C591-600
        }
}
The classic type of transient receptor potential channel (TRPC) is a molecular candidate for Ca(2+)-permeable cation channel in mammalian cells. TRPC5 is desensitized rapidly after activation by G protein-coupled receptor. Herein we report our investigation into the desensitization of mTRPC5 and localization of the molecular determinants of this desensitization using mutagenesis. TRPC5 was initially activated by muscarinic stimulation using 100 microM carbachol (CCh) and then decayed rapidly… CONTINUE READING

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