Desensitization of adenylate cyclase and cyclic AMP flux during the early stages of liver regeneration.

@article{Mahler1988DesensitizationOA,
  title={Desensitization of adenylate cyclase and cyclic AMP flux during the early stages of liver regeneration.},
  author={Stephen M. Mahler and Peter A. Wilce},
  journal={Journal of cellular physiology},
  year={1988},
  volume={136 1},
  pages={
          88-94
        }
}
Liver regeneration is controlled by a complex network of interactions between hormones, growth factors, and a variety of hepatotrophic factors. Transient increases in cAMP in the early stages of liver regeneration that are necessary for DNA synthesis and subsequent mitosis have been reported; however, studies on the mechanisms that control cellular cAMP levels during liver regeneration, namely adenylate cyclase activity, cAMP-dependent phosphodiesterase activity, and cAMP efflux from the cell… CONTINUE READING