Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure.

@article{Wyatt2004DesensitizationOP,
  title={Desensitization of PKA-stimulated ciliary beat frequency in an ethanol-fed rat model of cigarette smoke exposure.},
  author={Todd A Wyatt and Martha J. Gentry-Nielsen and Jacqueline A. Pavlik and Joseph H. Sisson},
  journal={Alcoholism, clinical and experimental research},
  year={2004},
  volume={28 7},
  pages={
          998-1004
        }
}
BACKGROUND Our previous studies have shown that the ciliary beat frequency (CBF) of cultured ciliated airway epithelial cells exposed to chronic ethanol fails to increase in response to beta-agonist stimulation. This loss of the ciliary "flight response" correlates with an ethanol-mediated desensitization of adenosine 3':5'-cyclic monophosphate-dependent protein kinase (PKA), a known regulatory component of CBF stimulation. We hypothesized that a similar ethanol-mediated desensitization of CBF… CONTINUE READING
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