Desensitization of Gamma Aminobutyric Acid (GABA) Receptors in Muscle Fibers of the Crab Cancer borealis

@inproceedings{Epstein1970DesensitizationOG,
  title={Desensitization of Gamma Aminobutyric Acid (GABA) Receptors in Muscle Fibers of the Crab Cancer borealis},
  author={Ren{\'e} Epstein and Harry Grundfest},
  booktitle={The Journal of general physiology},
  year={1970}
}
Carcinus muscle fibers respond to gamma-aminobutyric acid (GABA) with a conductance increase that subsides rather rapidly. In the larger fibers which have low input resistance the decrease may disappear within 2 min. The inhibition of the excitatory postsynaptic potentials (EPSP's) by GABA nevertheless persists as long as the drug is applied. The subsidence of the increased conductance indicates that the membrane of the inhibitory synapses has become desensitized to GABA. The persistence of… CONTINUE READING