Desensitization and re-sensitization of CGRP receptor function in human neuroblastoma SK-N-MC cells.

Abstract

Calcitonin gene-related peptide (CGRP) is a highly potent vasodilator known to be involved in many physiological functions within the cardiovascular, gastrointestinal, immune, and nervous systems. This study assessed the desensitization of CGRP receptors by measuring agonist-mediated activation of adenylate cyclase in a model system employing human… (More)

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