Desensitisation of calcitonin gene-related peptide responsiveness but not adrenomedullin responsiveness in vascular smooth muscle cells.

@article{Drake2000DesensitisationOC,
  title={Desensitisation of calcitonin gene-related peptide responsiveness but not adrenomedullin responsiveness in vascular smooth muscle cells.},
  author={W. Drake and Sarah Ryan Lowe and A Mirtella and Terri Bartlett and Anthony John Clark},
  journal={The Journal of endocrinology},
  year={2000},
  volume={165 1},
  pages={133-8}
}
Adrenomedullin (ADM) and calcitonin gene-related peptide (CGRP) are distantly related peptides. Both act through G protein-coupled receptors on vascular smooth muscle cells to increase intracellular cAMP concentrations, causing vasorelaxation. Recent evidence suggests that both peptides bind to a common heptahelical receptor, with specificity for each peptide being determined by a receptor activity modifying protein (RAMP). This hypothesis predicts that each peptide should desensitise the… CONTINUE READING