Description and power analysis of two tests for detecting recent population bottlenecks from allele frequency data.
@article{Cornuet1996DescriptionAP, title={Description and power analysis of two tests for detecting recent population bottlenecks from allele frequency data.}, author={Jean-Marie Cornuet and Gordon Luikart}, journal={Genetics}, year={1996}, volume={144 4}, pages={ 2001-14 } }
When a population experiences a reduction of its effective size, it generally develops a heterozygosity excess at selectively neutral loci, i.e., the heterozygosity computed from a sample of genes is larger than the heterozygosity expected from the number of alleles found in the sample if the population were at mutation drift equilibrium. The heterozygosity excess persists only a certain number of generations until a new equilibrium is established. Two statistical tests for detecting a…
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The patterns arising when populations undergo bottlenecks and then slowly recover are analysed, and two new statistical tests for the detection of the bottleneck are used, suggesting that the test is particularly suited for detecting relatively recent and strong bottlenECks and thus may be a valuable tool for identifying population events on a fine temporal scale.
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Simulation tests to compare methods for detecting recent bottlenecks using microsatellite data find that Mk was the method most likely to correctly identify a bottleneck when a bottleneck lasted several generations, the population had made a demographic recovery, and mutation rates were high or pre-bottleneck population sizes were large.
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