Descending serotonergic facilitation of spinal ERK activation and pain behavior.

@article{Svensson2006DescendingSF,
  title={Descending serotonergic facilitation of spinal ERK activation and pain behavior.},
  author={Camilla I. Svensson and Thao Kim Thi Tran and Bethany L Fitzsimmons and Tony L. Yaksh and Xiao-ying Hua},
  journal={FEBS letters},
  year={2006},
  volume={580 28-29},
  pages={6629-34}
}
Serotonin (5-HT) derived from bulbo-spinal projection is released by nociceptive input into the spinal dorsal horn. Here we report that formalin injection in the paw produced pain behavior (flinching) and phosphorylation of spinal ERK1/2 (P-ERK1/2, indicating activation) in rats. Depletion of spinal 5-HT by intrathecal (IT) 5,7-DHT, a serotonergic neurotoxin, profoundly reduced formalin evoked flinching and the increase in P-ERK1/2. Ondansetron (a 5-HT3 receptor antagonist) at IT doses that… CONTINUE READING