Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn

@article{Granton2008DescendingSC,
  title={Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn},
  author={Sandrine M G{\'e}ranton and Vincenza Fratto and Keri K. Tochiki and Stephen P. Hunt},
  journal={Molecular Pain},
  year={2008},
  volume={4},
  pages={35 - 35}
}
BACKGROUND Regulation of pain states is, in part, dependent upon plastic changes in neurones within the superficial dorsal horn. There is also compelling evidence that pain states are under the control of descending projections from the brainstem. While a number of transcription factors including Methyl-CpG-binding protein 2 (MeCP2), Zif268 and Fos have been implicated in the regulation of dorsal horn neurone sensitization following injury, modulation of their activity by descending controls… CONTINUE READING
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