Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils.

@article{Bulgarelli2009DesacylghrelinAS,
  title={Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils.},
  author={Ilaria Bulgarelli and Laura Tamiazzo and Elena Bresciani and Daniela Rapetti and Simona Caporali and Donatella Lattuada and Vittorio Locatelli and Antonio Torsello},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 12},
  pages={
          2718-27
        }
}
Data from Alzheimer's disease (AD) patients and AD animal models demonstrate the accumulation of inflammatory microglia at sites of insoluble fibrillar beta-amyloid protein (fAbeta) deposition. It is known that fAbeta binds to CD36, a type B scavenger receptor also involved in internalization of oxidized low-density lipoprotein (LDL), and initiate a signaling cascade that regulates microglial recruitment, activation, and secretion of inflammatory mediators leading to neuronal dysfunction and… CONTINUE READING
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