Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice

@article{Mahbod2018DesacylGD,
  title={Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice},
  author={Parinaz Mahbod and Eric P. Smith and M. Fitzgerald and Rachel L. Morano and B. Packard and S. Ghosal and Jessie R Scheimann and D. P{\'e}rez-Tilve and J. Herman and J. Tong},
  journal={Endocrinology},
  year={2018},
  volume={159},
  pages={388–399}
}
Ghrelin is a 28-amino acid polypeptide that regulates feeding, glucose metabolism, and emotionality (stress, anxiety, and depression). Plasma ghrelin circulates as desacyl ghrelin (DAG) or, in an acylated form, acyl ghrelin (AG), through the actions of ghrelin O-acyltransferase (GOAT), exhibiting low or high affinity, respectively, for the growth hormone secretagogue receptor (GHSR) 1a. We investigated the role of endogenous AG, DAG, and GHSR1a signaling on anxiety and stress responses using… Expand
GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress
The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders
The complex signaling pathways of the Ghrelin receptor.
...
1
2
...

References

SHOWING 1-10 OF 55 REFERENCES
Mice lacking ghrelin receptors resist the development of diet-induced obesity.
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.
Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress
Ghrelin increases anxiety-like behavior and memory retention in rats.
Des-acyl ghrelin: a metabolically active peptide.
...
1
2
3
4
5
...