Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.

  title={Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.},
  author={H. Cheong and E. J. Choi and G. Yoo and K. M. Kim and S. Ryu},
  journal={Planta medica},
  volume={64 6},
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property. It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and leucodin, were also examined and their IC50 values were determined as 100 microM and… Expand
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