Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin-Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin.

Abstract

Ghrelin is a stomach-derived octanoylated peptide hormone that plays a variety of well-established biological roles acting via its specific receptor known as growth hormone secretagogue receptor (GHSR). In plasma, a des-octanoylated form of ghrelin, named des-acyl ghrelin (DAG), also exists. DAG is suggested to be a signalling molecule that has specific… (More)
DOI: 10.1111/jne.12349

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@article{Fernandez2016DesAcylGD, title={Des-Acyl Ghrelin Directly Targets the Arcuate Nucleus in a Ghrelin-Receptor Independent Manner and Impairs the Orexigenic Effect of Ghrelin.}, author={G. Fernandez and Ana M. T. D. P. V. Cabral and Miglia Cornejo and P N De Francesco and Gema Garc{\'i}a-Romero and Mar{\'i}a Isabel L{\'o}pez Reynaldo and Manuel Perell{\'o}}, journal={Journal of neuroendocrinology}, year={2016}, volume={28 2}, pages={12349} }