Derricin and Derricidin Inhibit Wnt/β-Catenin Signaling and Suppress Colon Cancer Cell Growth In Vitro

  title={Derricin and Derricidin Inhibit Wnt/β-Catenin Signaling and Suppress Colon Cancer Cell Growth In Vitro},
  author={B. F. Fonseca and D. Predes and D. M. Cerqueira and Alice H. Reis and Nath{\'a}lia G. Amado and Marina C. L. Cayres and R. Kuster and F. L. Oliveira and F. Mendes and J. Abreu},
  journal={PLoS ONE},
Overactivation of the Wnt/β-catenin pathway in adult tissues has been implicated in many diseases, such as colorectal cancer. Finding chemical substances that can prevent this phenomenon is an emerging problem. Recently, several natural compounds have been described as Wnt/β-catenin inhibitors and might be promising agents for the control of carcinogenesis. Here, we describe two natural substances, derricin and derricidin, belonging to the chalcone subclass, that show potent transcriptional… Expand
18 Citations
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