Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.

@article{Schiller1989DermorphinAC,
  title={Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity.},
  author={Peter W. Schiller and Thi M.-D. Nguyen and Nga N. Chung and Carole Lemieux},
  journal={Journal of medicinal chemistry},
  year={1989},
  volume={32 3},
  pages={698-703}
}
According to the membrane compartment concept the receptor specificity of ligands is based not only on ligand-receptor complementarity but also on specific ligand-membrane interactions. Elaboration of this concept for opioid peptide-receptor interactions had led to the assumption that mu- and delta-receptors are located in anionic and cationic membrane compartments, respectively, and to the prediction that positively charged opioid receptor ligands should display mu-receptor selectivity. To… CONTINUE READING

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