Dermatophytic defensin with antiinfective potential.

  title={Dermatophytic defensin with antiinfective potential.},
  author={Shunyi Zhu and Bin Gao and Peta J. Harvey and David J. Craik},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 22},
Fungi are a newly emerging source of peptide antibiotics with therapeutic potential. Here, we report 17 new fungal defensin-like peptide (fDLP) genes and the detailed characterization of a corresponding synthetic fDLP (micasin) from a dermatophyte in terms of its structure, activity and therapeutic potential. NMR analysis showed that synthetic micasin adopts a "hallmark" cysteine-stabilized α-helical and β-sheet fold. It was active on both gram-positive and gram-negative bacteria, and… CONTINUE READING
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