Dermatofibrosarcoma protuberans is CD117 negative even after extreme antigen retrieval conditions.


Dermatofibrosarcoma protuberans (DFSP) is a malignant cutaneous tumor with a high rate of recurrence. Nevertheless, it responds to the drug Imatinib. The pathogenic mechanism why this drug works seems to be different to the inhibition of the Kit receptor of tyrosine kinase, since DFSP has repeatedly failed to express CD117 when immunohistochemically tested… (More)


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