Dermatitis herpetiformis sera or goat anti-transglutaminase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology.

@article{Zone2011DermatitisHS,
  title={Dermatitis herpetiformis sera or goat anti-transglutaminase-3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology.},
  author={John J. Zone and Linda A. Schmidt and T Bruce Taylor and Christopher M. Hull and Michael C Sotiriou and Troy D. Jaskowski and Harry Raymond Hill and Laurence J. Meyer},
  journal={Journal of immunology},
  year={2011},
  volume={186 7},
  pages={4474-80}
}
Dermatitis herpetiformis (DH) is characterized by deposition of IgA in the papillary dermis. However, indirect immunofluorescence is routinely negative, raising the question of the mechanism of formation of these immune deposits. Sárdy et al. (2002. J. Exp. Med. 195: 747-757) reported that transglutaminase-3 (TG3) colocalizes with the IgA. We sought to create such deposits using passive transfer of Ab to SCID mice bearing human skin grafts. IgG fraction of goat anti-TG3 or control IgG were… CONTINUE READING
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