Dermal tissue fibrosis in patients with chronic venous insufficiency is associated with increased transforming growth factor-beta1 gene expression and protein production.

@article{Pappas1999DermalTF,
  title={Dermal tissue fibrosis in patients with chronic venous insufficiency is associated with increased transforming growth factor-beta1 gene expression and protein production.},
  author={Peter J. Pappas and Ran You and Pranela Rameshwar and R Gorti and D O Defouw and Courtney K. Phillips and Frank Padberg and Michael B. Silva and Gregory T Simonian and Robert W. Hobson and Walter N. Dur{\'a}n},
  journal={Journal of vascular surgery},
  year={1999},
  volume={30 6},
  pages={1129-45}
}
PURPOSE Pathologic dermal degeneration in patients with chronic venous insufficiency (CVI) is characterized by aberrant tissue remodeling that results in stasis dermatitis, tissue fibrosis, and ulcer formation. The cytochemical processes that regulate these events are unclear. Because transforming growth factor-beta(1) (TGF-beta(1)) is a known fibrogenic cytokine, we hypothesized that the increased production of TGF-beta(1) would be associated with CVI disease progression. METHODS Seventy… CONTINUE READING
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