Corpus ID: 53591582

------------------------------------------------------------------------------------------------- Dermal stem cells are the target of the latest treatments for deep-seated skin regeneration

@inproceedings{Montao2012DS,
  title={------------------------------------------------------------------------------------------------- Dermal stem cells are the target of the latest treatments for deep-seated skin regeneration},
  author={Irene Monta{\~n}o},
  year={2012}
}
Fibroblasts are responsible for the continuous production of collagen and elastin. These proteins form the socalled extracellular matrix, a three dimensional structure that confers elasticity and firmness to the skin. Aging skin is characterized by an increasing number of senescent fibroblasts that have stopped producing collagen and elastin. The replacement of these senescent cells by new fibroblasts can only be provided by dermal stem cells. Stem cells are unspecialized cells with the… Expand
Plant stem cells culture — a new tool for skin protection and regeneration
TLDR
In vitro and in vivo studies demonstrated beneficial effects of plants stem cell extracts on human skin in the battle against ageing, to provide a review of studies based on the use of plant stem cells in limiting skin ageing. Expand

References

SHOWING 1-9 OF 9 REFERENCES
The role of cellular senescence in skin aging.
  • J. Campisi
  • Biology, Medicine
  • The journal of investigative dermatology. Symposium proceedings
  • 1998
TLDR
Senescent keratinocytes and fibroblasts appear to accumulate with age in human skin, and they express genes that have long-range, pleiotropic effects - degradative enzymes, growth factors, and inflammatory cytokines, which might compromise skin function and integrity. Expand
Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies
TLDR
Conclusions and future directions in relation to skin aging‐related disorders and cancer therapies targeting skin cancer stem/progenitor cells and their microenvironment are summarized. Expand
Aging epidermis is maintained by changes in transit-amplifying cell kinetics, not stem cell kinetics.
It has been assumed that the slow rate of healing in aging epidermis is due to slowing of the epidermal stem cell proliferative rate. In this issue, Charruyer et al. report that this may not be theExpand
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells.
TLDR
It is shown that skin-derived precursors (SKPs) derive from Sox2(+) hair follicle dermal cells and that these two cell populations are similar with regard to their transcriptome and functional properties. Expand
Plasticity revisited.
TLDR
It remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated, underscored by the recent demonstration of the extensive differentiation potential of mesenchymal stem cells. Expand
Hair follicle dermal papilla cells at a glance
TLDR
Mammalian skin is a highly tractable tissue in which to explore epithelial–mesenchymal interactions during development and in postnatal life and one population of these interactions is studied. Expand
Modelling the hair follicle dermal papilla using spheroid cell cultures
TLDR
Modelling the hair follicle dermal papilla using spheroid cell cultures with real-time PCR is shown to be a simple and straightforward process. Expand
stem/progenitor cell functions in skin regeneration, aging and cancers and novel antiaging and cancer therapies
  • J Cell Mol Med
  • 2010