Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: application of the EpiDerm human reconstructed epidermis model.

@article{Hu2009DermalPA,
  title={Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: application of the EpiDerm human reconstructed epidermis model.},
  author={Ting Hu and Ruth E Bailey and Stephen W Morrall and Marilyn J. Aardema and Lesley A. Stanley and Julie Ann Skare},
  journal={Toxicology letters},
  year={2009},
  volume={188 2},
  pages={119-29}
}
To address the provision of the 7th Amendment to the EU Cosmetics Directive banning the use of in vivo genotoxicity assays for testing cosmetic ingredients in 2009, the 3D EpiDerm reconstructed human skin micronucleus assay has been developed. To further characterise the EpiDerm tissue for potential use in genotoxicity testing, we have evaluated the dermal penetration and metabolism of two hair dye ingredients, p-aminophenol (PAP) and p-phenylenediamine (PPD) in this reconstructed epidermis… CONTINUE READING