Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation?

Abstract

2 Abstract Nitrite in/on the skin has potent antimicrobial effects and is believed to act as a local nitric oxide (NO) reservoir capable of modulating dermal cell function. Using male Wistar rats we here show that nitrite, when applied in neutral aqueous solution to the skin surface, readily permeates the dermis to reach the systemic circulation and cause… (More)
DOI: 10.1038/jid.2009.303

Topics

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Cite this paper

@article{GarcaSaura2010DermalNA, title={Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation?}, author={Mar{\'i}a Francisca Garc{\'i}a-Saura and Bernadette O. Fernandez and Brian P McAllister and David Whitlock and William W. Cruikshank and Martin Feelisch}, journal={The Journal of investigative dermatology}, year={2010}, volume={130 2}, pages={608-11} }