Dermal fibroblasts promote the migration of dendritic cells.

@article{Saalbach2010DermalFP,
  title={Dermal fibroblasts promote the migration of dendritic cells.},
  author={Anja Saalbach and Claudia Klein and Christine Schirmer and Wilfried Briest and Ulf Anderegg and Jan C. Simon},
  journal={The Journal of investigative dermatology},
  year={2010},
  volume={130 2},
  pages={444-54}
}
Migration of dendritic cells (DCs) from skin to lymph nodes on activation is an essential step in the initiation of an adequate immune response. The dermal microenvironment including stromal cells and their soluble factors might be involved in the regulation of DC migration. To focus on the role of dermal fibroblasts, we studied whether interaction of DCs with fibroblasts promotes the migration of DCs. DCs were co-cultured with resting fibroblasts or with tumor necrosis factor (TNF)alpha/IL… CONTINUE READING

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