Dermal developmental toxicity of N-phenylimide herbicides in rats.

@article{Kawamura2014DermalDT,
  title={Dermal developmental toxicity of N-phenylimide herbicides in rats.},
  author={S. Kawamura and Terushige Kato and M. Nakaoka and A. Fantel},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2014},
  volume={101 2},
  pages={
          162-7
        }
}
BACKGROUND S-53482 and S-23121 are N-phenylimide herbicides and produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats in conventional oral developmental toxicity studies. Our objective in this study was to investigate whether the compounds induce developmental toxicity via the dermal route, which is more relevant to occupational exposure, hence better addressing human health risks. METHODS S-53482 was administered dermally… Expand
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