Dermal dendritic cells associated with T lymphocytes in normal human skin display an activated phenotype.

@article{McLellan1998DermalDC,
  title={Dermal dendritic cells associated with T lymphocytes in normal human skin display an activated phenotype.},
  author={Alexander Donald McLellan and Axel Heiser and R{\"u}diger Volker Sorg and D B Fearnley and Derek N J Hart},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 5},
  pages={841-9}
}
The CMRF-44 and CD83 (HB15) antigens are associated with functional maturation and activation of blood dendritic cells (DC). We describe the expression of these antigens on freshly isolated epidermal Langerhans cells and dermal DC as well as the distribution of CD83+/ CMRF-44++-activated DC within sections of normal human skin. Fresh Langerhans cells were prepared by standard techniques and large numbers of enriched (25%-55%), viable dermal DC were obtained using an improved collagenase… CONTINUE READING
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