Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response.

@article{Fukunaga2008DermalDC,
  title={Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response.},
  author={Atsushi Fukunaga and Noor Mohammad Khaskhely and Coimbatore S. Sreevidya and Scott Napier Byrne and Stephen E. Ullrich},
  journal={Journal of immunology},
  year={2008},
  volume={180 5},
  pages={3057-64}
}
Langerhans cells (LCs) serve as epidermal sentinels of the adaptive immune system. Conventional wisdom suggests that LCs encounter Ag in the skin and then migrate to the draining lymph nodes, where the Ag is presented to T cells, thus initiating an immune response. Platelet-activating factor (PAF) is a phospholipid mediator with potent biological effects. During inflammation, PAF mediates recruitment of leukocytes to inflammatory sites. We herein tested a hypothesis that PAF induces LC… CONTINUE READING

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