Dermal and transdermal drug delivery systems: current and future prospects.

@article{Brown2006DermalAT,
  title={Dermal and transdermal drug delivery systems: current and future prospects.},
  author={Marc B. Brown and Gary P. Martin and Stuart A Jones and Franklin K. Akomeah},
  journal={Drug delivery},
  year={2006},
  volume={13 3},
  pages={175-87}
}
The protective function of human skin imposes physicochemical limitations to the type of permeant that can traverse the barrier. For a drug to be delivered passively via the skin it needs to have adequate lipophilicity and also a molecular weight <500 Da. These requirements have limited the number of commercially available products based on transdermal or dermal delivery. Various strategies have emerged over recent years to optimize delivery and these can be categorized into passive and active… CONTINUE READING

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