Dermal-Type Macrophages Expressing CD209/DC-SIGN Show Inherent Resistance to Dengue Virus Growth

@article{Kwan2008DermalTypeME,
  title={Dermal-Type Macrophages Expressing CD209/DC-SIGN Show Inherent Resistance to Dengue Virus Growth},
  author={Wing-Hong Kwan and Erika Navarro-S{\'a}nchez and H{\'e}l{\`e}ne Dumortier and Marion D{\'e}cossas and Hortense Vachon and Fl{\'a}via Barreto Dos Santos and Herv{\'e} W. Fridman and F{\'e}lix A Rey and E Harris and Philippe Despr{\'e}s and Christopher George Mueller},
  journal={PLoS Neglected Tropical Diseases},
  year={2008},
  volume={2},
  pages={2755 - 2766}
}
BACKGROUND An important question in dengue pathogenesis is the identity of immune cells involved in the control of dengue virus infection at the site of the mosquito bite. There is evidence that infection of immature myeloid dendritic cells plays a crucial role in dengue pathogenesis and that the interaction of the viral envelope E glycoprotein with CD209/DC-SIGN is a key element for their productive infection. Dermal macrophages express CD209, yet little is known about their role in dengue… CONTINUE READING