Dermal Microdialysis Sampling in Vivo

  title={Dermal Microdialysis Sampling in Vivo},
  author={Joseph M. Ault and Christopher M. Riley and Noel M. Meltzer and Craig Edward Lunte},
  journal={Pharmaceutical Research},
Microdialysis sampling of the dermis in vivo was accomplished using a linear microdialysis probe. In contrast to previous studies using a commercial cannula-style microdialysis probe, the linear probe had no effect on the flux of drug through the skin in vitro. The extent of tissue damage in vivo due to probe implantation was evaluated by histological examination and microdialysis delivery studies. Tissue damage due to implantation of the linear probe was minimal with no bleeding or edema… CONTINUE READING