Dermal Absorption of Camphor, Menthol, and Methyl Salicylate in Humans

@article{Martin2004DermalAO,
  title={Dermal Absorption of Camphor, Menthol, and Methyl Salicylate in Humans},
  author={D. Martin and J. Valdez and James Boren and M. Mayersohn},
  journal={The Journal of Clinical Pharmacology},
  year={2004},
  volume={44}
}
  • D. Martin, J. Valdez, +1 author M. Mayersohn
  • Published 2004
  • Chemistry, Medicine
  • The Journal of Clinical Pharmacology
  • Camphor, menthol, and methyl salicylate occur in numerous over‐the‐counter products. Although extensively used, there have been no estimates of human exposure following administration via dermal application. Furthermore, there is little information about the pharmacokinetics of those compounds. The authors report the plasma concentrations of the intact compounds as a function of dose following dermal patch application. Three groups of 8 subjects (4 male, 4 female) applied a different number of… CONTINUE READING
    67 Citations

    Topics from this paper

    Skin disposition of menthol after its application in the presence of drug substances
    • K. Cal
    • Chemistry, Medicine
    • Biopharmaceutics & drug disposition
    • 2008
    • 10
    Current Knowledge on the Vascular Effects of Menthol
    • H. Silva
    • Chemistry, Medicine
    • Frontiers in Physiology
    • 2020
    • 1
    • PDF
    The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats
    • 13
    • Highly Influenced
    • PDF
    Quantitation of Ten Flavor Compounds in Unburned Tobacco Products.
    • 17
    • PDF
    RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7.
    • A. M. Api, D. Belsito, +19 authors D. Wilcox
    • Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2015

    References

    SHOWING 1-10 OF 24 REFERENCES
    Effects of l-menthol and dl-camphor on the penetration and hydrolysis of methyl salicylate in hairless mouse skin.
    • 8
    Sensitive and selective gas chromatographic methods for the quantitation of camphor, menthol and methyl salicylate from human plasma.
    • 19
    Disposition kinetics and effects of menthol
    • 82
    Local necrosis and interstitial nephritis due to topical methyl salicylate and menthol.
    • 39
    Camphor ingestion for abortion (case report).
    • 29
    Camphor toxicity.
    • 23