Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination, and replication coordinated with tick feeding.

@article{Reif2011DermacentorAT,
  title={Dermacentor andersoni transmission of Francisella tularensis subsp. novicida reflects bacterial colonization, dissemination, and replication coordinated with tick feeding.},
  author={Kathryn E. Reif and Guy H. Palmer and Massaro W Ueti and Glen A. Scoles and Jeffrey J Margolis and Denise M Monack and Susan Marite Noh},
  journal={Infection and immunity},
  year={2011},
  volume={79 12},
  pages={4941-6}
}
Ticks serve as biological vectors for a wide variety of bacterial pathogens which must be able to efficiently colonize specific tick tissues prior to transmission. The bacterial determinants of tick colonization are largely unknown, a knowledge gap attributed in large part to the paucity of tools to genetically manipulate these pathogens. In this study, we demonstrated that Francisella tularensis subsp. novicida, for which a complete two-allele transposon mutant library has been constructed… CONTINUE READING