G protein-coupled receptors (GPCRs) constitute the largest known family of cell-surface receptors. With hundreds of members populating the rhodopsin-like GPCR superfamily and many more awaiting discovery in the human genome, they are of interest to the pharmaceutical industry because of the opportunities they afford for yielding potentially lucrative drug… (More)
Fig. 7. Diagnosis of a mosaic GPCR. The example illustrates the murine 7TM O35161, which contains multiple N-terminal cadherin repeats (white), a central EGF-containing domain (grey), followed by a C-terminal 7TM secretin-like signature (black).