Deriving structural and functional insights from a ligand-based hierarchical classification of G protein-coupled receptors.

@article{Attwood2002DerivingSA,
  title={Deriving structural and functional insights from a ligand-based hierarchical classification of G protein-coupled receptors.},
  author={Teresa K. Attwood and Mike D. R. Croning and Anna Gaulton},
  journal={Protein engineering},
  year={2002},
  volume={15 1},
  pages={7-12}
}
G protein-coupled receptors (GPCRs) constitute the largest known family of cell-surface receptors. With hundreds of members populating the rhodopsin-like GPCR superfamily and many more awaiting discovery in the human genome, they are of interest to the pharmaceutical industry because of the opportunities they afford for yielding potentially lucrative drug targets. Typical sequence analysis strategies for identifying novel GPCRs tend to involve similarity searches using standard primary database… CONTINUE READING